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A majority (75%) of Northern European patients have been found to have a mutation causing 57 kb deletion in the proximal region of CTNS , often extending to involve the upstream Sedoheptulose Kinase ( SHPK ) gene or into the adjacent Transient Receptor Potential Vanilloid-1 gene (TRPV1) [15,16]

510,511 Moreover, the HLA class I A*24 allele, which is implicated in increased predisposition to type 1 diabetes, negatively correlates with the presence of ZnT8A at and before diagnosis, taking into account the age at onset

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This restriction is due to the rigid nature of the amide (peptide) bond